Genomics,Multiomics

Dataset Information

0

RNA-sequencing of mouse double-negative developing thymocytes


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: Julien Roux  

PROVIDER: GSE118059 | GEO | 2019-02-04

REPOSITORIES: GEO

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Publications

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

Klein Fabian F   Mitrovic Mladen M   Roux Julien J   Engdahl Corinne C   von Muenchow Lilly L   Alberti-Servera Llucia L   Fehling Hans Jörg HJ   Pelczar Pawel P   Rolink Antonius A   Tsapogas Panagiotis P  

The Journal of experimental medicine 20190214 3


T cell development is critically dependent on successful rearrangement of antigen-receptor chains. At the β-selection checkpoint, only cells with a functional rearrangement continue in development. However, how nonselected T cells proceed in their dead-end fate is not clear. We identified low CD27 expression to mark pre-T cells that have failed to rearrange their β-chain. Expression profiling and single-cell transcriptome clustering identified a developmental trajectory through β-selection and r  ...[more]

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