Canine pimary osteosarcoma tissues vs. matched lung metastases

ABSTRACT: Osteosarcomas (OS) have highly chaotic genomes, yet their cancer drivers are poorly defined. Given that cancer genes are conserved among mammals, cross-species genomics of naturally arising cancers opens a powerful approach to identifying oncogenic drivers to broaden the therapeutic opportunities for aggressive cancers. Here, we utilized a dog-to-human cross-species genomics combined with gain- and loss-of-function analysis to uncover novel OS driver genes.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE118130 | GEO | 2021/08/03

REPOSITORIES: GEO