Genomics

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Single cell RNA-seq study of wild type and Hox mutant developing uterus


ABSTRACT: This study identifies a novel role for the Hoxc9,10,11 genes in uterine gland formation. This function is redundant with the Hoxa9,10,11 and Hoxd9,10,11 genes and is only seen in a sensitized genotype with reduced expression of these paralogs. We further used scRNA-seq to define the gene expression patterns of the multiple cell types of the developing uterus. The results define the gene expression patterns driving lineage specific development. In addition scRNA-seq was used to characterize the perturbed gene expression levels of all developing uterus cell types in the ACD+/- and ACD+/-WTA11 mutants. Particularly striking was the reduced Wnt signaling and the disruption of the Cxcl12/Cxcr4 axis in the mutants. Overall design: Using droplet RNA sequencing, transcriptomes of single cells from wild-type and Hox mutant mouse uteri were analyzed

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Steve Potter 

PROVIDER: GSE118180 | GEO | 2018-08-07

REPOSITORIES: GEO

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