Genomics

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Cadmium chloride-induced gene expression changes in D. melanogaster


ABSTRACT: Heavy metals and organic compounds, such as pesticides and plasticizers, exert toxicity through their ability to perturb molecular mechanisms. We investigated the ability of 18 compounds to modify the epigenetic state of the white locus in a Drosophila model of position-effect variegation (PEV). Our data indicate that cadmium chloride (CdCl2) is a potent enhancers of variegation. We demonstrate that genes differentially expressed upon CdCl2 exposure are enriched for genes that have heterochromatic states associated with them.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE118536 | GEO | 2019/08/01

REPOSITORIES: GEO

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