Transcriptomics

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IL-1 receptor antagonist controls transcriptional signature of inflammation in patients with metastatic breast cancer


ABSTRACT: Inflammation affects tumor immune surveillance and resistance to therapy. Here we show that production of interleukin (IL)-1b in primary breast cancer (BC) tumors is linked with advanced disease. Patients with metastatic HER2-negative BC display a transcriptional signature of inflammation in the blood, which is attenuated after IL1 blockade.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118646 | GEO | 2018/08/21

REPOSITORIES: GEO

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