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The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE118700 | GEO | 2019/01/28

REPOSITORIES: GEO

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The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila.

Project description: Not available

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The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila: differential ChIP-seq of CP190 and CLAMP under CP190 knockdown

Project description:Chromatin insulators are DNA-protein complexes that establish higher order independent DNA domains to influence transcriptional regulation. Insulators are defined by two different functions: they can block communication between an enhancer and a promoter and also act as a barrier between heterochromatin and euchromatin. In Drosophila, the gypsy-insulator complex contains three core components: Su(Hw), CP190 and Mod(mdg4)67.2. Here we identify a novel role for Chromatin-linked adaptor for MSL proteins (CLAMP) in promoting gypsy chromatin insulator function. When Clamp is depleted by RNAi, gypsy-dependent enhancer blocking activity decreases and barrier activity is reduced in all tissues. Furthermore, Clamp RNAi knockdowns and mutation result in disorganized insulator complex localization in the nucleus. Co-immunoprecipitation experiments showed that CLAMP physically associates with core gypsy-insulator proteins. Co-localization of CLAMP with gypsy components on polytene chromosomes and ChIP-seq analysis demonstrates co-localization of CLAMP with a subset of insulator sites across the genome. Thus, our findings suggest a ubiquitous, genome-wide role for CLAMP in promoting gypsy-dependent chromatin insulator activity.

2019-01-28 | GSE118699 | GEO

The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila

Project description:The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila

| PRJNA486506 | ENA

The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila: ChIP-seq of CP190, Su(Hw), Mod(mdg4) for genome-wide overlap with CLAMP

2019-01-28 | GSE103601 | GEO

The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.

Project description: Not available

| S-EPMC8240218 | biostudies-literature

The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila: differential ChIP-seq of CP190 and CLAMP under CP190 knockdown

Project description:The zinc-finger protein CLAMP promotes gypsy chromatin insulator function in Drosophila: differential ChIP-seq of CP190 and CLAMP under CP190 knockdown

| PRJNA486507 | ENA

Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein.

Project description: Not available

| S-EPMC5659772 | biostudies-literature