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Transcriptomic profiling of mRNA and miRNA from nasopharyngeal carcinoma (NPC) and normal control samples

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118721 | GEO | 2019/11/27

REPOSITORIES: GEO

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Transcriptomic profiling of nasopharyngeal carcinoma (NPC) and normal control samples

Project description:To understand the genes and pathways that may potentially drive nasopharyngeal carcinoma (NPC) pathogenesis, we sought out to analyze the transcriptomic data from the disease and control samples. We used RNA-sequencing based gene expression data to identify genes differentially expressed between NPC and normal controls and then characterize the gene ontology and pathways down- or up-regulated in the disease samples.

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miRNA-Seq profiling of nasopharyngeal carcinoma (NPC) and normal control samples

Project description:Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with nasopharyngeal carcinoma (NPC). EBV encodes two groups of microRNAs (miRNAs) which are divided into BamHI fragment H rightward open reading frame 1 (BHRF1) and BamHI-A rightward transcripts (BART) microRNAs. EBV miR-BARTs have been found to be involved in the development and progression of NPC. However, the role of EBV-miR-BARTs in NPC progression remains illusive. This study aimed to investigate the role of EBV-miR-BARTs in NPC and explore the underlying mechanisms.

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Transcriptomic profiling of mRNA and miRNA from nasopharyngeal carcinoma (NPC) and normal control samples

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Nasopharyngeal carcinoma (NPC) cell lines

Project description:5 EBV-free nasopharyngeal carcinoma cell lines expression patterns again normal epithelial tissues. Keywords: repeat sample

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Nasopharyngeal carcinoma (NPC) cell lines

Project description:5 EBV-free nasopharyngeal carcinoma cell lines expression patterns again normal epithelial tissues.

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Methylome study in Nasopharyngeal Carcinoma (NPC)

Project description:Aberrant methylation at the promoter region of tumor suppressors is frequently reported in NPC; however, genome-wide methylation changes have not been comprehensively investigated. Therefore, we systematically analyzed methylome data in 25 primary NPC tumors and non-tumor counterparts using Illumina HumanMethylation450 BeadChip.

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