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Genomic distribution of the cohesin subunit Stromalin (SA) in wild-type and Haspin knock-down Drosophila melanogaster Kc167 cells

ABSTRACT: Haspin is required for Drosophila SA binding to chromatin Keywords: Genome binding/occupancy profiling by high throughput sequencing

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE118813 | GEO | 2022/07/02

REPOSITORIES: GEO

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Genomic distribution of the cohesin subunit Stromalin (SA) in wild-type and Haspin knock-down Drosophila melanogaster Kc167 cells

Project description:Genomic distribution of the cohesin subunit Stromalin (SA) in wild-type and Haspin knock-down Drosophila melanogaster Kc167 cells

| PRJNA551978 | ENA

Genomic distribution of H3T3ph in Drosophila melanogaster S2 cells

Project description:Drosophila Haspin kinase phosphorylates Histone H3 at threonine 3 at centromeric heterochromatin and either lamin- or polycomb-enriched euchromatic regions, being required for nuclear organization of interphase cells and polycomb-dependent gene silencing.

2020-08-07 | GSE98223 | GEO

Dyella sp. Sa strain:Sa

Project description:Dyella sp. Sa strain:Sa Genome sequencing

| PRJNA845020 | ENA

Arabidopsis CBP60g Contributes to MAMP-Induced SA Accumulation and Is Involved in Disease Resistance

Project description:Salicylic acid (SA)-induced defense responses are important factors during effector triggered immunity and microbe-associated molecular pattern (MAMP)-induced immunity in plants. This article presents evidence that a member of the Arabidopsis CBP60 gene family, CBP60g, contributes to MAMP-triggered SA accumulation. CBP60g is inducible by both pathogen and MAMP treatments. Pseudomonas syringae growth is enhanced in cbp60g mutants. Expression profiles of a cbp60g mutant after MAMP treatment are similar to those of sid2 and pad4, suggesting a defect in SA signaling. Accordingly, cbp60g mutants accumulate less SA when treated with the MAMP flg22 or a P. syringae hrcC strain that activates MAMP signaling. MAMP-induced production of reactive oxygen species and callose deposition are unaffected in cbp60g mutants. CBP60g is a calmodulin-binding protein with a calmodulin-binding domain located near the N-terminus. Calmodulin binding is dependent on Ca2+. Mutations in CBP60g that abolish calmodulin binding prevent complementation of the SA production and bacterial growth defects of cbp60g mutants, indicating that calmodulin binding is essential for the function of CBP60g in defense signaling. These studies show that CBP60g constitutes a calmodulin-dependent link between MAMP recognition and SA accumulation that is important for resistance to P. syringae.

2009-01-15 | GSE14237 | GEO

Transcriptional profiling of wild-type (WT) and Ifnar1-SA (SA) in vitro differentiated Treg cells

Project description:Compared to wild-type (WT) Treg cells, Ifnar1-SA (SA) Treg cells have increased activity of IFN signaling pathways.

2021-08-15 | GSE182029 | GEO

Arabidopsis CBP60g Contributes to MAMP-Induced SA Accumulation and Is Involved in Disease Resistance

2010-05-07 | E-GEOD-14237 | biostudies-arrayexpress

Single cell analysis of tumor infiltrating immune cells in wild-type (WT) and Ifnar1-SA (SA) mice

Project description:Single cell analysis of tumor infiltrating CD8 T cells in wild-type (WT) and Ifnar1-SA (SA) mice identifies differentially expressed genes and signaling pathways.

2021-07-26 | GSE171055 | GEO

Transcriptional profiling of Populus leaves with altered SA levels

Project description:Salicylic acid (SA) has long been implicated in plant responses to oxidative stress. A direct assessment of SA effects in planta has been difficult, as SA-overproducing Arabidopsis mutants are compromised in growth or other developmental processes. We now report that transgenic Populus expressing a bacterial bifunctional SA synthase accumulated two to three orders of magnitude more total SA than wild type without affecting growth. Microarray experiments were performed to gauge the transcriptional responses of young source leaves to SA manipulation and/or heat stress. Differentially expressed genes due to SA perturbation or temperature treatment were identified. Co-expression network analysis was performed to identify key driver genes in SA-modulated response.

2013-08-01 | GSE42511 | GEO

Gated SA effect on transcriptome

Project description:We used microarrays to identify genes that respond to SA differently during the subjective morning and subjective night.

2015-06-22 | GSE61059 | GEO

Comprehensive Landscape of SA-AKI Revealed by Integrated Proteomics and Metabolomics Analysis

Project description:Sepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condi-tion with high morbidity and mortality among emergency patients, and it poses a sig-nificant risk of chronic renal failure. Clinical treatments for SA-AKI remain reactive and non-specific, lacking effective diagnostic biomarkers or treatment targets. In this study, we established an SA-AKI mouse model using LPS and performed proteomics and metabolomics analyses. A variety of bioinformatic analyses, including Gene Set En-richment Analysis (GSEA), Weighted Gene Co-expression Network Analysis (WGCNA), protein and protein interactions (PPI), and MetaboAnalyst analysis, were conducted to investigate the key molecules of SA-AKI. Proteomics and metabolomics analyses re-vealed that sepsis led to impaired renal mitochondrial function and metabolic disorders. Immune-related pathways were found to be activated in kidneys upon septic infection. The catabolic products of polyamines accumulated in septic kidneys. Overall, our study provides a more comprehensive understanding of SA-AKI and identifies potential pathways for this condition.

2023-10-24 | PXD044371 | Pride

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