Unraveling a mechanism driving poor-prognosis prostate cancer: overexpression of the DNA repair gene, ribonucleotide reductase small subunit M2

ABSTRACT: FOXM1 activated RRM2 drives poor outcomes in major PC subtype classifications (PCS and PAM50 classifiers),and targeting RRM2 and its key TFs (e.g. FOXM1) abrogate PC progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE118845 | GEO | 2019/05/01

REPOSITORIES: GEO