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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

ABSTRACT: Purpose: The purpose is to systemically identify RNA expression between skin mast cells with distinct origins. Methods: We profiled RNA-seq in skin mast cells with distinct origins. Results: Early, late EMP and fetal HSC-derived skin mast cells display distinct transcriptome profiles.

ORGANISM(S): Mus musculus

PROVIDER: GSE119016 | GEO | 2018/10/05

REPOSITORIES: GEO

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Purpose: The purpose is to systemically identify RNA expression changes along mast cell development during embryogenesis. Methods: We profiled RNA-seq in early EMPs and their progeny. Results: Fetal MCPs acquire the mast cell-specific gene signature from E11.5 and complete their maturation in peripheral tissues.

2018-10-15 | GSE119017 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-09 | GSE119018 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

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Human connective tissue mast cell proteome

Project description:Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products confer protection against snake venoms and some parasite infections. Aberrant activation of mast cells is a major contributor to human pathology, including allergy, asthma and adverse drug reactions. Their strict tissue location has largely impeded the isolation of large numbers of primary mast cell for further analysis. To better understand the biology of mast cells, we analyzed the proteome of primary human and mouse mast cells by quantitative mass spectrometry. We identified a mast cell-specific protein signature that was conserved from mouse to man. Compared to a comprehensive set of other immune cell lineages, proteome analysis identified a unique and distant mast cell cluster. The mast cell signature included proteins governing granule biosynthesis and secretion, as well as proteoglycan- and neurotransmitter metabolism. Proteome conservation across species suggests evolutionary maintenance of mast cell functions.

2020-02-12 | PXD014978 | Pride

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

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Analysis of gene expressions of mast cells in murine atopic dermatitis-like skin

Project description:Purpose: To compare gene expressions of resident and integrinβ7-positive mast cells (MCs) in atopic-dermatitis (AD) like skin. Methods: Each MC population from skin was sorted by flow cytometry, and sequencing was performed on Illumina HiSeq 4000 platform. Sequencing data in the form of FASTQ files were mapped onto the Mus musculus genome build GRCm38 using the STAR aligner (version 2.5.2b) with gene annotations obtained from GENCODE (version M22). Differential expression analysis was performed using the edgeR package (version 3.28.1) in R (version 3.6.2) and differentially expressed genes were defined as those with false discovery rate (FDR) < 0.05. Results: Principal component analysis demonstrated three distinct MC populations, and 1157 differentially expressed genes were detected. Integrinβ7-positive MC showed both mucosal type mast cell signatures and skin type mast cell signatures, and they specifically expressed migration related genes.

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Project description:Comparison of gene expression profiles of mast cells isolated from lesional psoriatic and healthy volunteer skin

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