Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human Treg NaCl stimulation

ABSTRACT: Human Tregs isolated from PBMCs were cultured in the absence or presence of additional NaCl (40mM) for four days and were performed mRNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE119192 | GEO | 2018/08/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Human Treg IL-12 stimulation

Project description:Human Tregs isolated from PBMCs were cultured in the absence or presence of IL-12 (20ng/ml) for four days and were performed mRNA-seq.

2018-08-30 | GSE119191 | GEO

Human Treg NaCl stimulation

Project description:Human Treg NaCl stimulation

| PRJNA488438 | ENA

Expression data from Regulatory T Cells either exposed to normal salt media or high salt media (+40mM NaCl)

Project description:Sodium Chloride Inhibits Suppressive Function of Foxp3+ Regulatory T Cells Given the functional changes observed secondary to exposure to high-salt we wanted to know what expression based changes were taking place in the regulatory T cell population that might help to explain the evidenced functional deficits. Regulatory T Cells (Tregs) were incubated either in the presence or absence of an additional 40mM NaCl for 3 days with anti-CD3/anti-CD28 to ascertain phenotypic and expression based changes in the cellular population.

2014-11-18 | E-GEOD-63327 | biostudies-arrayexpress

High salt reduces the activation of IL-4+IL-13 stimulated macrophages

Project description:High salt (NaCl) intake is a major risk factor for cardiovascular disease; high NaCl has also been shown to be a powerful modulator of pro-inflammatory immune cell polarization. To investigate the effect of high NaCl on the polarization of M(IL-4+IL-13) macrophages we performed gene expression analysis by microarray and genome wide histone modification (H3K4me3 and H4ac) analysis by ChIP-seq of murine bone marrow derived macrophages. Macrophages were polarized with recombinant IL-4 and IL-13 in vitro in the presence or absence of an additional 40mM of NaCl in the culture medium for 24h before analysis.

2015-02-07 | E-MTAB-3140 | biostudies-arrayexpress

High salt reduces the activation of IL-4+IL-13 stimulated macrophages

2014-12-16 | E-MTAB-3163 | biostudies-arrayexpress

NaCl reactors

Project description:NaCl reactors Metagenome

| PRJNA690829 | ENA

Human Treg IFNg/IL-10 subpopulations

Project description:Human Tregs isolated from PBMCs were sorted into 4 different subpopulations based on IFNg and IL-10 production and were performed mRNA-seq.

2018-08-30 | GSE116283 | GEO

Transcriptomic analysis of a NaCl-resistant Saccharomyces cerevisiae mutant obtained by evolutionary engineering

Project description:NaCl-resistant Saccharomyces cerevisiae mutant was obtained by evolutionary engineering. EMS mutagenized culture was used as the initial population for the selection procedure. Gradually increasing levels of NaCl stress was applied through 40 successive batch cultivations. The reference strain could not grow even at 0.85 M NaCl whereas this mutant was shown to be resistant up to 1.45 M NaCl concentration. Whole-genome microarray analysis was used to identify the NaCl resistance mechanisms by comparing NaCl-resistant mutant strain and the reference strain in the absence of NaCl stress.

2014-09-30 | GSE61903 | GEO

0.3M NaCl vs Control and 2M NaCl vs Control

Project description:Transcriptional profiling of Deinococcus radiodurans comparing control untreated wild type cells with wild type cells treated with 0.3M NaCl or 2M NaCl

2011-05-26 | GSE29516 | GEO

JHMV-specific Treg memory

Project description:Regulatory T cells (Tregs) are critical for regulating immunopathogenic responses in a variety of infections, including infection of mice with JHMV, a neurotropic coronavirus that causes immune-mediated demyelinating disease. While virus-specific Tregs are known to mitigate disease in this infection by suppressing pathogenic effector T cell responses of the same specificity, it is unclear if these virus-specific Tregs form memory populations and persist similar to their conventional T cell counterparts of the same epitope specificity. Using congenically labeled JHMV-specific Tregs, we found that virus-specific Tregs persist long-term after infection, through at least 180 days post-infection. We additionally demonstrate that these cells are better able to proliferate after infection than naïve Tregs of the same specificity, further suggesting that these cells differentiate into memory Tregs upon encountering cognate antigen. Together, these data suggest that virus-specific Tregs are able to persist long-term in the absence of viral antigen as memory Tregs.

2021-08-12 | GSE181728 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data