Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Microarray-based comparative genomic profiling of reference strains of Actinobacillus pleuropneumoniae

ABSTRACT: Microarray-based comparative genomic hybridizations were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. Our goal was to identify conserved genes, especially those predicted to encode outer membrane proteins and lipoproteins because of their potential for the development of more effective vaccines. Keywords: Comparative Genomic Hybridisation

ORGANISM(S): Actinobacillus pleuropneumoniae serovar 5b str. L20 Actinobacillus pleuropneumoniae

PROVIDER: GSE11921 | GEO | 2009/02/03

SECONDARY ACCESSION(S): PRJNA105765

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Microarray-based comparative genomic profiling of reference strains of Actinobacillus pleuropneumoniae

Project description:Microarray-based comparative genomic hybridizations were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. Our goal was to identify conserved genes, especially those predicted to encode outer membrane proteins and lipoproteins because of their potential for the development of more effective vaccines. Keywords: Comparative Genomic Hybridisation Microarray data for 15 known serotypes of Actinobacillus pleuropneumoniae (at least 2 replicates per serotype).

2009-02-02 | E-GEOD-11921 | biostudies-arrayexpress

Comparative genomic profiling of reference strains and selected Canadian field isolates of A. pleuropneumoniae

Project description:Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is a highly contagious respiratory pathogen that causes severe losses to the swine industry worldwide. Current commercially-available vaccines are of limited value because they do not induce cross-serovar immunity and do not prevent development of the carrier state. Microarray-based comparative genomic hybridizations (M-CGH) were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. Our goal was to identify conserved genes, especially those predicted to encode outer membrane proteins and lipoproteins because of their potential for the development of more effective vaccines. Using hierarchical clustering, our M-CGH results showed that the majority of the genes in the genome of the serovar 5 A. pleuropneumoniae L20 strain were conserved in the reference strains of all 15 serovars and in representative field isolates. Fifty-eight conserved genes predicted to encode for outer membrane proteins or lipoproteins were identified. As well, there were several clusters of diverged or absent genes including those associated with capsule biosynthesis, toxin production as well as genes typically associated with mobile elements. Keywords: Comparative Genomic Hybridization

2009-01-31 | GSE14639 | GEO

Comparative genomic profiling of reference strains and selected Canadian field isolates of A. pleuropneumoniae

2009-01-30 | E-GEOD-14639 | biostudies-arrayexpress

Actinobacillus pleuropneumoniae during a natural infection in pigs

Project description:Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease which causes great economic losses worldwide. Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. In order to identify genes that are expressed in vivo during a natural infection, we undertook transcript profiling experiments with an A. pleuropneumoniae DNA microarray, after recovery of bacterial mRNAs from serotype 5b-infected porcine lungs. Comparative Genomic Hybridizations between Actinobacillus pleuropneumoniae serotype 5b strain L20 (ref) and serotype 5b fresh field isolate 896-07, recovered from infected pig lung tissues following natural acute infection. Two condition transcript profiling experiments : infectious 5b field strain isolated directly from lungs of naturally deceased pigs after acute infection vs infectious 5b field strain grown in BHI broth to an OD600 of 0.300.

2010-05-05 | E-GEOD-15911 | biostudies-arrayexpress

Actinobacillus pleuropneumoniae BHI vs Koromycin

Project description:Actinobacillus pleuropneumoniae is the etiologic agent of contagious pleuropneumonia, an economically important disease of commercially reared swine throughout the world. To cause this disease, A. pleuropneumoniae must rapidly overcome porcine pulmonary innate immune defenses. Effects of koromycin, an antimicrobial agent that acts as an noncompetitive inhibitor of the interaction of NQR with its quinone substrate, on the transcriptome of A. pleuropneumoniae was investigated.

2009-01-06 | GSE13116 | GEO

Transcriptome of 6h static biofilm Actinobacillus pleuropneumoniae

Project description:The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

2013-05-20 | GSE43821 | GEO

Transcriptome of 4h static biofilm Actinobacillus pleuropneumoniae

Project description:The transcriptome of Actinobacillus pleuropneumoniae biofilms was compared to the transcriptome of planktonic bacteria

2013-05-20 | GSE43820 | GEO

Actinobacillus pleuropneumoniae

Project description:Microarray-based comparative genomic profiling of reference strains of Actinobacillus pleuropneumoniae

| PRJNA105765 | ENA

Genomic hybridization of several Actinobacillus pleuropneumoniae serotypes' reference strains compared to strain JL03

Project description:To make clear the genetic diversity and virulence evolution at the genome-wide level of A. pleuropneumoniae Keywords: comparative genomic hybridization

2009-11-11 | GSE13629 | GEO

Genome-wide screening and characterization of Actinobacillus pleuropneumoniae and its ciprofloxacin-resistant mutants

Project description:Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Actinobacillus pleuropneumoniae and its ciprofloxacin resistance-inducing derivatives.This study aims to explore the mechanism of acquired ciprofloxacin resistance in Actinobacillus pleuropneumoniae.

2021-10-06 | GSE181030 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data