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Topoisomerase II inhibition involves characteristic chromosomal expression patterns

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE11942 | GEO | 2008/10/01

SECONDARY ACCESSION(S): PRJNA105795

REPOSITORIES: GEO

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Topoisomerase II inhibition involves characteristic chromosomal expression patterns.

Project description: Not available

| S-EPMC2488358 | biostudies-literature

Topoisomerase II inhibition involves characteristic chromosomal expression patterns: Trovafloxacin study

Project description:Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. Specific members of this drug family display high activity against eukaryotic type II topoisomerase, as well as cultured mammalian cells and in vivo tumor models. Trovafloxacin seems to have a higher affinity for eukaryotic polymerase II system than the other quinolone agents tested. This effect coupled with other factors, such as an inflammatory response, might result in a hepatotoxic reaction seen with drug. In this study we found genes regulated by trovafloxacin - induced and repressed - to be located much closer to each other than genes distributed randomly all over the genome (< 100 kbp). Keywords: Trovafloxacin-treated human hepatocytes versus non-treated human hepatocytes

2008-10-01 | GSE11941 | GEO

Topoisomerase II inhibition involves characteristic chromosomal expression patterns: Doxorubicin study

Project description:A variety of important anticancer drugs kill cells by increasing cellular levels of topoisomerase II-DNA cleavage complex. The anthracycline anticancer drug doxorubicin forms a stable ternary complex with DNA and topoisomerase IIa, thereby inhibiting the normal function of the enzyme. In this study we found genes regulated by doxorubicin - induced and repressed - to be located much closer to each other than genes distributed randomly all over the genome (< 100 kbp). Keywords: Doxorubicin-treated human hepatocytes versus non-treated human hepatocytes

2008-10-01 | GSE11940 | GEO

Topoisomerase II inhibitors and histone eviction

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-04 | E-GEOD-33634 | biostudies-arrayexpress

Co-ordinate inhibition of autism candidate genes by topoisomerase inhibitors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-30 | E-GEOD-43900 | biostudies-arrayexpress

Topoisomerase II inhibitors and histone eviction