Transcriptomics,Genomics

Dataset Information

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MiRNA profiles of lung tissues from Mtb H37Rv infected C57B/6 mice and uninfected controls


ABSTRACT: The C57B/6 mice were infected with Mtb H37Rv (CFU=200) for 28 days, and the miRNA expression profile from lung tissues were analyzed with deep sequencing. Overall design: miRNA profiles of lung tissues from Mtb H37Rv infected C57B/6 mice and uninfected controls were generated by deep sequencing, in triplicate.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Feng Liu  

PROVIDER: GSE119496 | GEO | 2018-09-06

REPOSITORIES: GEO

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Publications

MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy.

Liu Feng F   Chen Jianxia J   Wang Peng P   Li Haohao H   Zhou Yilong Y   Liu Haipeng H   Liu Zhonghua Z   Zheng Ruijuan R   Wang Lin L   Yang Hua H   Cui Zhenling Z   Wang Fei F   Huang Xiaochen X   Wang Jie J   Sha Wei W   Xiao Heping H   Ge Baoxue B  

Nature communications 20181016 1


Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills millions every year, and there is urgent need to develop novel anti-TB agents due to the fast-growing of drug-resistant TB. Although autophagy regulates the intracellular survival of Mtb, the role of calcium (Ca2+) signaling in modulating autophagy during Mtb infection remains largely unknown. Here, we show that microRNA miR-27a is abundantly expressed in active TB patients, Mtb-infected mice and macrophages. The target of miR-27  ...[more]

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