Genomics

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Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Alexander Ploss  

PROVIDER: GSE119751 | GEO | 2018-11-28

SECONDARY ACCESSION(S): GSE119750 GSE119749

REPOSITORIES: GEO

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Publications

Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses.

Douam Florian F   Ziegler Carly G K CGK   Hrebikova Gabriela G   Fant Bruno B   Leach Robert R   Parsons Lance L   Wang Wei W   Gaska Jenna M JM   Winer Benjamin Y BY   Heller Brigitte B   Shalek Alex K AK   Ploss Alexander A  

Nature communications 20181128 1


Mice engrafted with components of a human immune system have become widely-used models for studying aspects of human immunity and disease. However, a defined methodology to objectively measure and compare the quality of the human immune response in different models is lacking. Here, by taking advantage of the highly immunogenic live-attenuated yellow fever virus vaccine YFV-17D, we provide an in-depth comparison of immune responses in human vaccinees, conventional humanized mice, and second gene  ...[more]

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