Genomics

Dataset Information

0

Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-derived Parietal Bone through Downregulation of Fgf23


ABSTRACT: Purpose: This study investigates the postnatal impact of Twist1 haploinsufficiency on the osteoskeletal ability and regeneration on two calvarial bones arising from tissues of different embryonic origin: the neural crest-derived frontal and the mesoderm-derived parietal bones. Results: Twist1 haplonsufficiency selectively enhanced osteogenic and tissue regeneration ability of mesoderm-derived parietal bones. Twist1 haplonsufficiency triggers its selective activity on mesoderm-derived parietal bone through downregulation of the bone-derived hormone Fgf23. Conclusions: Twist1 haploinsufficiency preferentially triggers osteogenic induction of parietal bones which may be beneficial to optimize treatments for skeletal regeneration, reconstruction and repair of mesoderm-derived bone, as well as to alleviate skeletal abnormalities caused by Twist1 haploinsufficiency.

ORGANISM(S): Mus musculus

PROVIDER: GSE119962 | GEO | 2018/09/15

REPOSITORIES: GEO

Similar Datasets

| PRJNA490833 | ENA
2011-06-30 | GSE30167 | GEO
2021-06-17 | GSE163693 | GEO
2023-10-21 | GSE245664 | GEO
| E-GEOD-62816 | biostudies-arrayexpress
2022-02-24 | PXD006865 | Pride
| E-GEOD-81430 | biostudies-arrayexpress
| E-GEOD-80335 | biostudies-arrayexpress
2020-05-18 | GSE144944 | GEO
| E-GEOD-80662 | biostudies-arrayexpress