P. aeruginosa PAO wildtype Cy3 PA3898 mutant Cy5

ABSTRACT: We present here a transcriptional regulator, PA3898, which controls biofilm formation and multidrug efflux-pumps in P. aeruginosa. A mutant of this regulator significantly reduced the ability of P. aeruginosa to produce biofilm in vitro, and affected its in vivo fitness and pathogenesis in Drosophila melanogaster and BALB/c mouse lung infection models. Transcriptome analysis revealed that PA3898 modulates essential virulence genes/pathways, including multidrug efflux-pumps and phenazine biosynthesis.

ORGANISM(S): Pseudomonas aeruginosa

PROVIDER: GSE120009 | GEO | 2018/09/16

REPOSITORIES: GEO