Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE120039 | GEO | 2018/10/11

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RRBS]

Project description:Uniparental reproduction is widespread among lower vertebrates, but not in mammals. Researchers have produced bimaternal mice with a deletion of the H19 imprinted region. However, the mechanism of a single deletion in an immature oocyte sufficient to cross uniparental barriers is unknown. We found bimaternal-derived mice to be defective in multiple aspects. More importantly, bipaternal reproduction has not been achieved in mammals. Thus, the barrier of uniparental reproduction in mammals has not been elucidated. We identified a DNA hypomethylation status in haploid embryonic stem cells similar to that in primordial germ cells, with which bimaternal and bipaternal mice can be obtained by injection of haploid ES cells with genetic modifications. The phenotypic analyses of derived mice support the genetic conflict theory of genomic imprinting. Taken together, our results highlight the factors necessary for crossing uniparental reproduction barriers in mammals.

2018-10-12 | GSE120036 | GEO

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RNA-Seq]

2018-10-12 | GSE120037 | GEO

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells

Project description:Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells

| PRJNA491428 | ENA

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RRBS]

Project description:Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RRBS]

| PRJNA491433 | ENA

Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RNA-Seq]

Project description:Dissection of uniparental reproduction barriers in mice using haploid embryonic stem cells [RNA-Seq]

| PRJNA491432 | ENA