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Homo sapiens whole genome expression microarray of endometrium obtained from fertile and Infertile women with stage IV ovarian endometriosis and without endometriosis

ABSTRACT: The hypothesis that male michrochimerism in eutopic endometrium is a factor for endometriosis, as indicated by indirect evidence was examined in endometrial samples from control (Group 1) and stage IV ovarian endometriosis (Group 2), either fertile (Group 1A and 2A) or Infertile (Group 1B and 2B) pateints. 6 coding and 10 non-coding genes showed bi-modal pattern of expression characterised by low expression in samples obtained from fertile patients and high expressions in infertile patients. Several coding and non-coding MSY-linked genes displayed michrochimerism in form of presence of their respective DNA inserts along with their microarray-detectable expression in endometrium irrespective of fertility history and disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE120103 | GEO | 2019/02/26

REPOSITORIES: GEO

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Homo sapiens whole genome expression microarray of endometrium obtained from fertile and Infertile women with stage IV ovarian endometriosis and without endometriosis

Project description:Homo sapiens whole genome expression microarray of endometrium obtained from fertile and Infertile women with stage IV ovarian endometriosis and without endometriosis

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Comparative Proteomics Indicates Metformin Ameliorates Endometrial Receptivity of infertile women with Endometriosis

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Project description:We performed gene expression analysis human peritoneal endometriosis lesions, eutopic endometrium from endometriosis patients and peritoneum form endometriosis patients.The goal of the study was to analyse gene expression differences between peritoneal endometriosis lesion and eutopic endometrium and peritoneal endometriosis lesion and peritoneum.

2012-12-06 | E-MTAB-694 | biostudies-arrayexpress

Proteomics of endometriosis

Project description:This project aims at comparing endometrium from women with and without endometriosis during the secretory phase of menstrual cycle. The present results constitute a first step towards identifying potential diagnosis biomarkers and may provide a better understanding of endometriosis especially the etiology of the disease.

2022-04-01 | PXD012981 | Pride

Gene expression profiles of endometriosis

Project description:Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we carried out transcriptome:microRNAome analysis of endometriomas and eutopic endometrium, using gene expression arrays and next generation small RNA sequencing technology. Keywords: two group comparison Patients undergoing surgery for endometriomas, suspected endometriosis, pelvic pain, abnormal uterine bleeding, pelvic organ prolapse, or uterine leiomyomas were approached for participation. After informed consent, the patients underwent scheduled surgical procedure. Tissues were collected either as cyst wall of endometrioma or endometrial curettage of hysterectomy specimen and placed directly into RNALater (Ambion, Austin, TX) and eventually frozen at -80?C. Samples were designated as endometriomas or non-endometriosis control endometrium based on surgical pathology reports. Total RNA was isolated from frozen tissue. High quality RNA was subjected to Illumina’s Human WG-6 version 2.0 BeadChips (Illumina). . *** This Series represents the transcriptome component of the study. ***

2011-05-09 | E-GEOD-23339 | biostudies-arrayexpress

Complement Roles Revealed by Immune Gene Profiling in Endometriosis and Endometriosis-Associated Ovarian Cancer

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2015-01-07 | E-GEOD-57545 | biostudies-arrayexpress

Gene expression profiles of endometriosis

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Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity

Project description:To investigate the different function of endometriosis-related infertile patients follicular fluid (EMFF) and follicular fluid in control group (COFF), follicular fluid was collected and used for RNA sequencing.

2022-06-15 | GSE205494 | GEO

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Project description:Caput epididymides biopsies from 4 patients suffering from non-obstructive azoospermia and from 4 patients with active spermatogenesis were compared. 414 genes in the caput epididymides were differentially regulated in infertile men by at least a 2-fold change as compared to the fertile men. Keywords: Comparison of infertile and fertile caput epididymides

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