Studies in an early development window unveils a severe HSC defect in both murine and human Fanconi anemia [mouse]

ABSTRACT: We performed a unique kinetics study of hematopoiesis in Fancg-/- mouse embryos, between E12.5 and E14.5 developmental window. We also report for the first time that a deep HSC defect is also observed during human FA development, and that human FA FL HSCs present a transcriptome profile similar to that of mouse E12.5 Fancg-/- FL HSCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE120167 | GEO | 2018/11/30

REPOSITORIES: GEO