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Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin

ABSTRACT: The study of dominantly heritable cancers has provided significant insights about tumor development. Basal cell nevus syndrome (BCNS), or Gorlin syndrome (OMIM #109400), is an autosomal dominant inherited disorder that is characterized by developmental abnormalities and postnatal occurrence of various neoplasms, principally basal cell carcinomas (BCCs). We performed an exploratory gene expression profiling of primary cultures, including keratinocytes and fibroblasts derived from clinically unaffected skin biopsies of BCNS gene-carriers (PTCH1 +/-) and normal individuals.

ORGANISM(S): Homo sapiens

PROVIDER: GSE120242 | GEO | 2019/03/20

REPOSITORIES: GEO

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