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C-Maf is an essential commitment factor for IL-17-producing gd T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE120427 | GEO | 2018/12/03

REPOSITORIES: GEO

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c-Maf is an essential commitment factor for IL-17-producing gd T cells [ATAC-seq]

Project description:IL-17-producing gd T (Tgd17) cells are early mediators of immunity and autoimmunity that undergo effector programming in the thymus. While Vg subset-restricted regulators of Tgd17 specialization are known, a universal type 17 commitment factor for all gd T cells remains undefined. In this study, we identify the transcription factor c-Maf as an essential and uniform regulator of Tgd17 differentiation and maintenance. The absolute lineage block caused by Maf deficiency reveals a critical effector acquisition checkpoint at the immature CD24+ CD45RBlo gd thymocyte stage. Here, c-Maf enforces Tgd17 identity by promoting chromatin accessibility and activating expression of lineage-defining RORgt and key type 17 program genes, while coordinately antagonizing the negative regulator TCF1, which promotes the alternative IFNg+ Tgd1 fate. During specialization, c-Maf expression is tuned by gdTCR signal strength, implicating c-Maf as a rheostat controlling effector gd T cell generation and connecting gdTCR signals to a core node in the Tgd17 network.

2018-12-03 | GSE120426 | GEO

c-Maf is an essential commitment factor for IL-17-producing gd T cells [RNA-seq]

2018-12-03 | GSE120425 | GEO

The transcription factor c-Maf is essential for the commitment of IL-17-producing ?? T cells.

Project description: Not available

| S-EPMC6294311 | biostudies-literature

c-Maf is an essential commitment factor for IL-17-producing gd T cells

Project description:c-Maf is an essential commitment factor for IL-17-producing gd T cells

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c-Maf is an essential commitment factor for IL-17-producing gd T cells [RNA-seq]

Project description:c-Maf is an essential commitment factor for IL-17-producing gd T cells [RNA-seq]

| PRJNA493053 | ENA