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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [blood]


ABSTRACT: Blood, bronchial epithelium, and bronchio-alveolar cells were collected in a double blind study. Individuals were exposed to 'ground' and 'flight' conditions using a hypobaric chamber for approximately 5 hours. Blood samples were collected over 4 time points and both bronchial cells were collected at the last time point. Overall design: Samples were collected from 20 individuals, comprised of 10 smokers and 10 nonsmokers. Both subgroups of smokers and nonsmokers were comprised of 5 males and 5 females each. Collection timepoint 1 = taken at time 0, before exposure to 'altitude' Collection timepoint 2 = taken after 30 minutes exposure to 'altitude' Collection timepoint 3 = taken after 4 hours exposure to 'altitude' Collection timepoint 4 = taken 1.5 hours after exposure to 'altitude' ended

INSTRUMENT(S): [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]

ORGANISM(S): Homo Sapiens

SUBMITTER: Susan Kasko Munster  

PROVIDER: GSE120906 | GEO | 2021-09-14

REPOSITORIES: GEO

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