Genomics

Dataset Information

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Single-cell RNA-seq of splenic Treg and Tconv cells


ABSTRACT: While unique subsets of Treg cells have been described in some non-lymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. We have identified a short-lived effector Treg cell subset that expresses the α2 integrin, CD49b, and exhibits a unique tissue distribution. Projection of the CD49b+ Treg signature onto the Treg phenotypic landscape as inferred by single-cell RNA-seq analysis, placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.

ORGANISM(S): Mus musculus

PROVIDER: GSE121034 | GEO | 2018/10/22

REPOSITORIES: GEO

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