Dataset Information


Single Nucleotide Resolution Analysis of Nucleotide Excision Repair of Ribosomal DNA in Humans and Mice

ABSTRACT: In the present work we have applied analytical methods to map repair events in rDNA using data generated by the newly developed XR-seq genome-wide single nucleotide repair technology. We find that in human and mouse cell lines, rDNA is not subject to TCR of damage caused by UV or by cisplatin. Overall design: We perform XR-seq in mouse skin fibroblast under UV irradiation and collect cells after incubation 3 hours. For human cell lines NHF1, CSB and XPC, we perform XR-seq under UV irradiation and collect cells after incubation 1 hour. For GM12878, we perform XR-seq under cisplatin and collect cells after incubation 2 hours. Then we mapped all the reads to rDNA or DHFR. This dataset includes re-analysis of five GSE67941 Samples and two GSE82213 Samples.


INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Yanyan Yang  

PROVIDER: GSE121042 | GEO | 2018-11-24


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