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Differential CpG methylation in peripheral naive and memory CD4+T-cells, and monocytes in early rheumatoid arthritis patients

ABSTRACT: The genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation and many T-cells genes with a strong MHC-association, pointing to immuno-genetic mechanisms as disease triggers. We aim to identify methylation change in naive and memory CD4+T-cells and monocytes in the early stage of disease, to gain insight to disease pathology. DNA-methylation was explored using a genome wide array (DNA methylation Illumina 450K bead chip array). Differential methylation in promoters of many genes was associated with several disease relevant pathways notably in naive CD4+T-cells. This pointed to the IL6/JAK1/STAT3 signalling cascade linking into inflammatory mechanisms and TNF signalling as well as the engagement of naive CD4 T-cells intoTh17 differentiation and the implication of several Interferon response genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121192 | GEO | 2020/04/20

REPOSITORIES: GEO

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