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Perivascular niche cells sense thrombocytopenia and activate platelet-biased HSCs in an IL-1 dependent manner

ABSTRACT: RNA sequencing analysis of stromal cells, haematopoietic stem cells and megakaryocytes from mice in homeostasis and after platelet depletion

ORGANISM(S): Mus musculus

PROVIDER: GSE121249 | GEO | 2021/10/15

REPOSITORIES: GEO

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Perivascular niche cells sense thrombocytopenia and activate platelet-biased HSCs in an IL-1 dependent manner

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RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production

Project description:RNA sequencing was performed to identify gene expression changes following SRSF3 depletion in mouse bone marrow megakaryocytes and peripheral blood platelets.

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Expression of thioredoxin-interacting protein (TXNIP) during megakaryopoiesis is indispensable for platelet biogenesis

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