Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene Expression Profile in Peripheral Blood Nuclear Cells of Small Ruminant Lentivirus-Seropositive and Seronegative Dairy Goats in Their First Lactation

ABSTRACT: The study investigated differences in gene expression profiles of peripheral blood nuclear cells sampled from healthy and infected with SRLV goats, belonging to two breeds. Due to the nature of the lentiviral infection we hypothesized that the virus could induce genes expression regulation. We put forward the hypothesis that if gene expression differences exist, they should be revealed in studies conducted on custom-made Capra hircus Gene Expression Array. The results revealed that SRLV infection results in regulation of several genes in goat’s peripheral blood nuclear cells.

ORGANISM(S): Capra hircus

PROVIDER: GSE121259 | GEO | 2021/03/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Real-time quantitative PCR analysis of goat mammary glands in peak-lactation and late-lactation periods

Project description:In comparison with cow milk, goat (Capra hircus) milk contains much higher levels of unsaturated fatty acids, as well as higher levels of total fat, proteins, carbohydrates, calcium, and vitamins.The main objective of the present study was to better define the relationship of known miRNAs regulating milk fat metabolism. Our main purpose is to search for some known miRNAs regulating milk fat metabolism, to this end, we screened potential miRNAs with differential expression between peak-lactation and non-lactation. qPCR gene expression profiling. Monocytes from three healthy goats (3 year old) of similar body weight. We screened a series of potential miRNAs involved in regulation of milk metabolism.

2016-06-25 | E-GEOD-83706 | biostudies-arrayexpress

Gene Expression Profile in Peripheral Blood Nuclear Cells of Small Ruminant Lentivirus-Seropositive and Seronegative Dairy Goats in Their First Lactation.

Project description: Not available

| S-EPMC8066113 | biostudies-literature

Gene Expression Profile in Peripheral Blood Nuclear Cells of Small Ruminant Lentivirus-Seropositive and Seronegative Dairy Goats in Their First Lactation

Project description:Gene Expression Profile in Peripheral Blood Nuclear Cells of Small Ruminant Lentivirus-Seropositive and Seronegative Dairy Goats in Their First Lactation

| PRJNA496498 | ENA

Capra hircus breed:Grey Goats

Project description:Capra hircus breed:Grey Goats Transcriptome or Gene expression

| PRJNA471199 | ENA

Real-time quantitative PCR analysis of goat mammary glands in peak-lactation and late-lactation periods

2016-06-25 | GSE83706 | GEO

Identification of transcriptional biomarkers by RNA-sequencing for improved detection of ß2-agonists abuse in goat skeletal muscle

Project description:RNA-sequence is applied to reveal gene expression frofiles of β2-agonist in capra hircus

2017-08-31 | GSE97479 | GEO

Functional genome and microbiome in blood of goats affected by the gastrointestinal pathogen Haemonchus contortus

Project description:The Alpine goat Capra aegagrus hircus is parasitized by the barber pole worm (Haemonchus contortus). This relationship results in changes that affect the gene expression of the host, the pest, and the microbiome of both. Hematological parameters indicating genes that are expressed and/or the % Composition of abundant and diverse microbial flora are reflective of infestation. We identified responses to barber pole worms using blood-based analysis of transcripts and the microbiome. Seven (7) days post-inoculation (dpi) we identified 7,627 genes associated with different treatment types.

2021-03-26 | GSE169607 | GEO

Transcriptome-wide search for Carpathian goat factors associated with proviral load of small ruminant lentiviruses in goats

Project description:Purpose: RNA-sequencing (RNA-seq) was used to identify the changes in gene expression in goats carrying high (HPL) and low (LPL) proviral load of SRLV. For the first time, differentially expressed transcriptome profiles in these two group of animals were identified, and information about genes and mechanisms, and relevant pathways inferred via bioinformatics analyses. The results provided unique insights for further exploring and understanding the host responses to SRLV infection in goats. Results: Data enabled to identify 1434 significant differentially expressed genes between HPL and LPL goats. Of these genes, 571 were upregulated and the remaining 863 genes were downregulated in HPL goats. GO enrichment analysis showed that the identified DEGs were found to have significantly enriched regulation of signaling receptor activity, the response to toxic substance, NADH dehydrogenase complex assembly, cytokine production, vesicle and vacuole organization. In turn, KEGG pathway tool classified DEGs that enrich molecular processes such as B and T cell receptor signaling pathways, natural killer cell-mediated cytotoxicity, Fc gamma R-mediated phagocytosis, toll-like receptor signaling pathways, TNF, mTOR signaling and Foxo signaling pathway, etc. Conclusions: In this descriptive study, our findings revealed the changes in the host transcriptome expression profile between HPL and LPL goats during SRLV infection and suggested that changes in proviral load induced altering the host’s metabolic network and expression of genes related to host immune responses, including inflammation, cell locomotion, cytokine production, defense response etc. The above findings provided unique insights for further studies on the mechanisms underlying SRLV-host interactions.

2021-03-04 | GSE168160 | GEO

A Comparison of Oxidative Stress Biomarkers in the Serum of Healthy Polish Dairy Goats with Those Naturally Infected with Small Ruminant Lentivirus in the Course of Lactation.

Project description: Not available

| S-EPMC8300365 | biostudies-literature

NextGen project sequencing goats from Australia

Project description:Low coverage sequencing of Capra hircus from Australia

| PRJEB4371 | ENA