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RNA-seq of colon tissue from wild type and Elf4-/- mice with colitis

ABSTRACT: ELF4 is a transcription factor, and to identify its potential targets, the inflamed colons of wild type and Elf4 deficient mice were subjected to whole genome RNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE121305 | GEO | 2019/10/16

REPOSITORIES: GEO

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RNA-seq of spleen tissue of wild type and Elf4 deficient mice after Plasmodium yoelii 17XNL infection

Project description:We infected wild type and Elf4 deficient mice with Plasmodium yoelii 17XNL, a non-lethal species, to investigate and compare anti-Plasmodium response of two groups of mice.

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RNA-seq of bone marrow tissue of wild type and Elf4 deficient mice after Plasmodium yoelii 17XNL infection

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RNA-seq of colon tissue from wild type and Elf4-/- mice with colitis

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Gene expression signatures for ELF4

Project description:To elucidate how ELF4 confers anti-growth activity, gene expression profiles were compared between wildtype- and mutant-expressing T3M-1 Cl-10 cells with the use of DNA microarrays. T3M-1 Cl-10 cells were infected with a mock retrovirus or virus generated from pMXS-ires-EGFP expressing ELF4 or ELF4(L211M), and EGFP?positive fractions were purified with a cell sorter. Thus gene expression profiling of purely mock/ELF4/ELF4(L211M)-expressing cells was performed with SurePrint G3 Human Gene Expression 8×60K v2 Microarray.

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Genome-wide screening for ELF4-binding sites.

Project description:ELF4 (also known as MEF) is a member of the ETS family of transcriptional factors. While an oncogenic role has been demonstrated for ELF4 mainly in hematopoietic malignancies, its definitive function in human carcinogenesis is not clear yet. Here we demonstrate that a wide array of human tumors carry somatic, loss-of-function mutations in ELF4 for its transcriptional activity, and restoring its function exerts anti-proliferative effects. To further explore the tumor suppressive function of ELF4, its binding sites were searched among the human genome with the use of chromatin immunoprecipitation coupled with sequencing (ChIP-seq). Examination of binding site for FLAG-immunoprecipitated mock, ELF4 (WT) and ELF4 (L211M) with each input sample as a control.

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Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and ELF4-/- CACO2 cells Transcriptomes

Project description:Conclusion: RNA sequencing of Wild Type and ELF4-/- CACO2 cells.

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Genome-wide screening for ELF4-binding sites.

2016-03-01 | GSE53357 | GEO

Control of CD8+ T cell proliferation by the transcription factor ELF4

2009-03-24 | GSE15324 | GEO

Transcription profiling of mouse CD8+ T cells from wild type and Elf4-/- mice left untreated or activated in vitro by culturing on anti-CD3 coated plates and anti-CD28 in media

Project description:Transcription factors that regulate quiescence, proliferation, and homing of lymphocytes are critical for effective immune system function. In the present study, we demonstrated that the transcription factor ELF4 directly activates the tumor suppressor KLF4 downstream of T cell receptor (TCR) signaling to induce cell cycle arrest in naÃ¯ve CD8+ T cells. Elf4- and Klf4-deficient mice accumulated CD8+CD44hi T cells during steady-state conditions and generated more memory T cells after immunization. The homeostatic expansion of CD8+CD44hi T cells in Elf4-null mice resulted in a redistribution of cells to non-lymphoid tissue due to reduced expression of the transcription factor KLF2, and the surface proteins CCR7 and CD62L. This work describes the combinatorial role of lymphocyte-intrinsic factors in the control of T cell homeostasis, activation and homing. Experiment Overall Design: CD8 T cells were purified from spleen of wild type and Elf4-/- mice and CD8 T cells were left untreated or activated in vitro by culturing on anti-CD3 coated plates and anti-CD28 in media (RPMI 10% FBS supplemented with 5% T-stim) for 3.5 days. Experiment Overall Design: RNAs isolated from wild type and Elf4 -/- CD8+ T cells were used in Affimetrix oligonucleotide arrays either untreated or after 3.5 days of activation.

2009-03-28 | E-GEOD-15324 | biostudies-arrayexpress

Gene expression signatures for ELF4

2013-12-04 | GSE52855 | GEO

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