Dataset Information


Evaluating the effect of CovR phosphorylation on group A streptococcus global gene expression

ABSTRACT: We sought to determine how CovRS mutations varying CovR phosphorylation levels affect the gene expression profile of group A streptococcus Overall design: There were 8 strains analyzed, each in quadruplicate replicates: 1) wild-type GAS serotype M1; 2) covS-E281A GAS serotype M1; 3) covS-T284A GAS serotype M1 4) covR-D53A GAS serotypep M1; 5) wild-type GAS serotype M3; 6) covS-E281A GAS serotype M3; 7.) covS-T284A GAS serotype M1; 8.) covR-D53A GAS serotypep M3

INSTRUMENT(S): Illumina HiSeq 2000 (Streptococcus sp. 'group A')

SUBMITTER: Samuel Shelburne  

PROVIDER: GSE121313 | GEO | 2018-10-19


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Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus.

Horstmann Nicola N   Tran Chau Nguyen CN   Brumlow Chelcy C   DebRoy Sruti S   Yao Hui H   Nogueras Gonzalez Graciela G   Makthal Nishanth N   Kumaraswami Muthiah M   Shelburne Samuel A SA  

PLoS pathogens 20181031 10

The control of virulence regulator/sensor kinase (CovRS) two-component system is critical to the infectivity of group A streptococcus (GAS), and CovRS inactivating mutations are frequently observed in GAS strains causing severe human infections. CovS modulates the phosphorylation status and with it the regulatory effect of its cognate regulator CovR via its kinase and phosphatase activity. However, the contribution of each aspect of CovS function to GAS pathogenesis is unknown. We created isoall  ...[more]

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