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Expression data from testis in mutant mouse lacking retinoic acid synthesizing enzymes in germ cells

ABSTRACT: In mammals, all-trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH) present notably in germ cells (GC). In order to determine the contributions of the GC-derived source of ATRA, we have generated mice lacking all RALDH activities in GC. We show that the GC-derived source of ATRA does not perform any specific role despite contributing to two-third of the total amount of ATRA present in the testis.

ORGANISM(S): Mus musculus

PROVIDER: GSE121326 | GEO | 2018/11/30

REPOSITORIES: GEO

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