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Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways

ABSTRACT: We examined the transcriptional changes modulated by estrogen receptor beta (ERβ) by performing global transcriptome analysis. U87 cells were transduced with lentiviral particles carrying either empty vector or ERβ-FLAG expression vector and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that ERβ modulated genes were related to homologous recombination, DNA damage response, ATM signaling and cell cycle pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121332 | GEO | 2019/05/02

REPOSITORIES: GEO

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