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Transcriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)

ABSTRACT: Vertebrate eye devlopment is partially regulated by thyroid hormones. Propylthiouracyl is a pharmaceutical that lowers thyroid hormone levels. We investigated the effects of PTU on eye development of zebrafish. We expected PTU exposure to cause transcriptional changes of visual-system-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. Additionally, the reversibility of effects after recovery in clean water for three days was investigated.

ORGANISM(S): Danio rerio

PROVIDER: GSE121334 | GEO | 2019/05/09

REPOSITORIES: GEO

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Transcriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)

Project description:Transcriptional profile of zebrafish eyes after exposure to 350 mg/L Propylthiouracyl (PTU)

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INDUCED HYPER (T3) AND HYPO (PTU) THYROIDISM AFFECT TRANSCRIT PROFILE IMMUNE RESPONSES IN RAINBOW TROUT HEAD KIDNEY

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