Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE121393 | GEO | 2018/11/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Project description: Not available

| S-EPMC6303294 | biostudies-literature

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells [Human 10x]

Project description:IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4+ T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3Neg CD4+ T cells that displays regulatory activity unlike other IL-10-producing CD4+ T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4+ T cells with regulatory function from others and to identify them across different tissues and disease models in mice and humans. These regulatory IL-10-producing Foxp3Neg CD4+ T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Finally, we found that patients with Inflammatory Bowel Disease (IBD), demonstrate a deficiency in this specific regulatory T-cell subpopulation.

2018-11-07 | GSE121267 | GEO

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells [Mouse 10x]

2018-11-07 | GSE121287 | GEO

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells [Mouse SMART-seq2]

2018-11-07 | GSE121386 | GEO

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells [Mouse Bulk-seq]

2018-11-07 | GSE121284 | GEO

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

Project description:Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

| PRJNA497253 | ENA

Co-expression of CD163 and CD141 Identifies Human Circulating IL-10-Producing Dendritic Cells (DC-10)

Project description:This SuperSeries is composed of the SubSeries listed below.