Transcriptional profiling of 5 days post LPC lesion after microglia ablation

ABSTRACT: Following all types of neurological injury, resident macrophages are activated locally, and blood-derived macrophages are recruited. Distinguishing the role of resident and blood-derived macrophages is complicated by the difficulty in distinguishing between these cell types because they mostly express the same molecular markers in a diseased state. To begin to understand the complexity of functions of resident and blood-derived macrophages following acute injury in the central nervous system (CNS) we ablated microglia, but not infiltrating macrophages, to determine their contribution following lysolecithin-induced demyelination .

ORGANISM(S): Mus musculus

PROVIDER: GSE121484 | GEO | 2020/01/15

REPOSITORIES: GEO