Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from yeast with Anc1p or without under basal or MMS exposed conditions

ABSTRACT: We are investigating the transcriptional response of Anc1 deficient yeast under basal and MMS exposed conditions We used microarrays to detail the global programme of gene expression underlying the MMS response in WT and Anc1 deficient yeast Keywords: dose

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE12150 | GEO | 2008/11/01

SECONDARY ACCESSION(S): PRJNA113763

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of yeast with Anc1p or without under basal or MMS exposed conditions

Project description:We are investigating the transcriptional response of Anc1 deficient yeast under basal and MMS exposed conditions; We used microarrays to detail the global programme of gene expression underlying the MMS response in WT and Anc1 deficient yeast Experiment Overall Design: Yeast strains either WT or Anc1 deficient were exposed or unexposed to MMS

2008-11-13 | E-GEOD-12150 | biostudies-arrayexpress

Transcription profiling of mouse Aag glycosylase knockout vs. Wild type treated with MMS alkylating agent

Project description:We are investigating the transcriptional response of mice that are wt or null for Aag in response to alkylating agent MMS; We used microarrays to detail the global programme of gene expression response due to MMS exposure in a DNA repair proficient or deficient mouse Experiment Overall Design: Mice (WT and Aag null) were treated with MMS and livers extracted at 6, 12, 24, and 48 hours

2009-02-21 | E-GEOD-11252 | biostudies-arrayexpress

Aag glycosylase and impact on gene expression changes

Project description:We are investigating the transcriptional response of mice that are wt or null for Aag in response to alkylating agent MMS We used microarrays to detail the global programme of gene expression response due to MMS exposure in a DNA repair proficient or deficient mouse Keywords: timepoint

2009-02-04 | GSE11252 | GEO

RNA-seq of OPI1 knockout yeast cells and the effect of methyl methanesulfonate (MMS) treatment relative to wild-type yeast cells with or without MMS treatment

Project description:Methyl methanesulfonate (MMS) is a DNA damage agent that induces the DNA damage response (DDR). Recent findings in the literature suggest a role for phosphatidylinositol signaling in regulating the DDR. In budding yeast, inositol biosynthesis is fine-tuned by the transcriptional repressor Opi1. We conducted RNA-seq of OPI1 knockout and wild-type yeast cells in conditions with or without treatment with 0.1% MMS for 1 hour to investigate the role of Opi1 in the response to genotoxic stress.

2023-07-05 | E-MTAB-13057 | biostudies-arrayexpress

Low-level MMS treatment of S.cerevisiae

Project description:The cellular response to treatment with DNA-damaging substances at low concentrations which are genotoxic but do not have a strong cytotoxic effect are of special interest. In addition, environmental variations that influence growth conditions, e.g. different media, and individual fitness, e.g. different strains, are likely to influence and modulate the adverse effects of individual DNA damaging substances. At sub-cytotoxic levels, DNA damaging substances play an important role in the accumulation of genomic mutations. In longer living organisms, like humans and other mammals, exposure to DNA damaging substances over extended period of time is a critical factor that contributes to the development of various diseases and in particular of tumors. The aim of our work was to study how strain background and growth conditions influence respond to DNA damage caused by low doses of MMS and which part of these changes is responsible for their sensitivity to toxic conditions. We analyzed sensitivity of two yeast strains FF18984 and BY4742 to MMS in media with limited and full nutrient availability. Keywords: Yeast, S.cerevisiae, MMS, stress response, DNA damage

2007-06-26 | GSE8237 | GEO

Translational and transcriptional responses of fission yeast to MMS

Project description:Ribosome profiling was used to investigate how Schizosaccharomcyes pombe cells modulate gene expression in response to methyl methanesulfonate (MMS)

2020-11-18 | E-MTAB-8745 | biostudies-arrayexpress

Expression data from yeast treated with enediynes compared to gamma radiation

Project description:We are investigating the transcriptional response of yeast to treatment with enediynes or gamma radiation, which generate different extents of double or single strand breaks in DNA. We used microarrays to detail the global programme of gene expression underlying the DNA damage response in yeast Keywords: dose

2006-10-16 | GSE5301 | GEO

Expression data from yeast with modulated expression of base excision repair players

Project description:We are investigating the transcriptional response of yeast to modulation of the expression of base excision repair players, these generate different dna lesions of abasic sites of strand breaks We used microarrays to detail the global programme of gene expression underlying the DNA damage response in yeast Keywords: dose

2007-11-30 | GSE9295 | GEO