MEF2C interaction profiles (4C-seq) in SH-SY5Y and HEK cell lines

ABSTRACT: To characterize enhancer elements regulating the MEF2C gene during neurodevelopment, we performed among others Circularized Chromosome Conformation Capture (4C) sequencing in a neuronal cell line, SH-SY5Y, and a non-neuronal control, HEK. We found that, in a neuronal cell line, the MEF2C promoter interacts with several putative enhancer elements in its upstream region, forming a complex interaction network. Moreover, these interactions are completely absent in HEK cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121549 | GEO | 2018/10/22

REPOSITORIES: GEO