CRISPR screen for interferon-alpha inducible inhibitors of yellow fever virus replication

ABSTRACT: Host cells produce interferon (IFN) in response to viral infections. Secreted interferon results in the transcription and production of hundreds of interferon-stimulated genes (ISGs). A genome-wide CRISPR screen using IFN alpha-treated Huh7.5 cells was performed to determine which ISGs were required in order for host cells to suppress yellow fever virus (YFV) infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121710 | GEO | 2018/10/25

REPOSITORIES: GEO