Neuroprotective effect of miR-204 OE in mouse models of Inherited Retinal Disease (IRD)

ABSTRACT: Transcriptome profile of retinas from wild-type (c57BL/6) and RHO-P347S mice following AAV-mediated subretinal delivery of pre-miR-204 to study the molecular changes underlying the neuroprotective effect of miR-204 OE in mouse models of Inherited Retinal Disease (IRD) To determine the molecular changes associated with AAV-mediated delivery of miR-204 in the subretinal space of wild-type and IRD mouse models, we performed RNASeq analysis of retinas from c57BL/6 and RHO-P347S mice injected with the AAV2/8.CMV.miR204 and AAV2/8.CMV.miR204MUT vector in a paired manner.

ORGANISM(S): Mus musculus

PROVIDER: GSE121785 | GEO | 2019/12/02

REPOSITORIES: GEO