RNAseq of Islet CD11c+ cells and Islet T cells from 12-20 week non-obese diabetic mice

ABSTRACT: Using intravital 2-photon islet imaging we show that T cell extravasation into the islets is an extended process, with T cells arresting in the islet vasculature in close proximity to perivascular CD11c+ cells. Antigen is not required for T cell trafficking to infiltrated islets, but T cell chemokine receptor signaling is necessary. Using RNAseq, we show that islet CD11c+ cells express over 20 different chemokines that bind chemokine receptors expressed on islet T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE121804 | GEO | 2019/03/01

REPOSITORIES: GEO