MiRNA profiles of exosomes secreted by head and neck cancer-associated fibroblasts and the paired normal fibroblasts

ABSTRACT: Exosomal miRNAs secreted by cancer-associated fibroblasts (CAFs) play a critical role in facilitating head and neck cancer (HNC) progression. A few studies in other cancers have confirmed some CAF-specific miRNAs could be delivered to tumor cells via exosome, thus contributing to chemoresistance. To identify the specific miRNAs responsible for the capability of CAF-derived exosomes to promote cisplatin resistance in recipient HNC cells, a miRNA array was conducted to identify miRNAs involved in exosomes derived from CAFs and the paired normal fibroblasts (NFs).

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE121848 | GEO | 2018/10/27

REPOSITORIES: GEO