Unregulated APC activation by T cells breaks self-tolerance

ABSTRACT: The absence of nTregs results in slight increase of B7 on dendritic cells (DC). Such slightly elevated B7 induce proliferation of T cells with intrinic high self-affinity: bidirectional T/DC interaction ensues, leading to progressive DC activation and reciprocal strong T cell activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE121882 | GEO | 2019/01/23

REPOSITORIES: GEO