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Dissecting cell composition and cell-cell interaction network of human disease heart tissue by single-cell sequencing

ABSTRACT: We studied the cell compositon of two types of human heart disease (coronary atherosclerotic heart disease and dilated cardiomyopathy) by single-cell sequencing. Distinct subgroups of cardiac muscle, fibroblast cell and endothelial cell were detected. We generated a cell-cell interaction network using specific expressed ligands and receptors of cells. And we also observed the change of interaction and cell transformation with age.

ORGANISM(S): Homo sapiens

PROVIDER: GSE121893 | GEO | 2019/10/21

REPOSITORIES: GEO

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Dissecting cell composition and cell-cell interaction network of normal human heart tissue by single-cell sequencing

Project description:We studied the cell compositon of normal human heart by single-cell sequencing. Distint subgroups of cardiac muscle, fibroblast cell and endothelial cell were detected. We drawed a cell-cell interaction network using specific expressed ligands and receptors of cells. And we also observed the change of interaction and cell transformation with age.

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YAP-TEAD multiphasic activation regulates pluripotent stem cell mechanics to drive cardiac specification and contractility in pathological heart.

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