Dataset Information

MiR-Seq on paired skin and oral mucosal wound healing

ABSTRACT: To delineate the role of microRNAs in the site-specific injury response, we compared the microRNAome of skin and oral mucosa both at baseline and throughout the time course of wound healing. Overall design: miR-Seq based microRNA profiling was performed on tissue samples acquired from a murine wound healing model of paired skin and oral mucosal wounds throughout the wound healing process (0 hr, 6 hr, 24 hr and 5 days post-wounding).

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Xiaofeng Zhou

PROVIDER: GSE121996 | GEO | 2019-05-29

REPOSITORIES: GEO

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Dataset's files

Source:

			Action	DRS
	GSE121996_Report_6956-Comparison_miRNA.xlsx	Xlsx

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Publications

Differential microRNA profile underlies the divergent healing responses in skin and oral mucosal wounds.

Simões Alyne A Chen Lin L Chen Zujian Z Zhao Yan Y Gao Shang S Marucha Phillip T PT Dai Yang Y DiPietro Luisa A LA Zhou Xiaofeng X

Scientific reports 20190509 1

Oral mucosal wounds heal faster than skin wounds, yet the role of microRNAs in this differential healing has never been examined. To delineate the role of microRNAs in this site-specific injury response, we first compared the microRNAome of uninjured skin and oral mucosa in mice. A total of 53 tissue-specific microRNAs for skin and oral mucosa epithelium were identified. The most striking difference was the high abundance of miR-10a/b in skin (accounting for 21.10% of the skin microRNAome) as co ...[more]

PMID: 31073224

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