Dataset Information


MiR-Seq on paired skin and oral mucosal wound healing

ABSTRACT: To delineate the role of microRNAs in the site-specific injury response, we compared the microRNAome of skin and oral mucosa both at baseline and throughout the time course of wound healing. Overall design: miR-Seq based microRNA profiling was performed on tissue samples acquired from a murine wound healing model of paired skin and oral mucosal wounds throughout the wound healing process (0 hr, 6 hr, 24 hr and 5 days post-wounding).

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Xiaofeng Zhou  

PROVIDER: GSE121996 | GEO | 2019-05-29


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Differential microRNA profile underlies the divergent healing responses in skin and oral mucosal wounds.

Simões Alyne A   Chen Lin L   Chen Zujian Z   Zhao Yan Y   Gao Shang S   Marucha Phillip T PT   Dai Yang Y   DiPietro Luisa A LA   Zhou Xiaofeng X  

Scientific reports 20190509 1

Oral mucosal wounds heal faster than skin wounds, yet the role of microRNAs in this differential healing has never been examined. To delineate the role of microRNAs in this site-specific injury response, we first compared the microRNAome of uninjured skin and oral mucosa in mice. A total of 53 tissue-specific microRNAs for skin and oral mucosa epithelium were identified. The most striking difference was the high abundance of miR-10a/b in skin (accounting for 21.10% of the skin microRNAome) as co  ...[more]

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