Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism

ABSTRACT: The paradox of tumor immunology is that tumor infiltrating lymphocytes (TILs) are dysfunctional in situ and yet are capable of stem cell-like behavior with self-renewal, massive expansion, multipotency, and eradication of large metastatic tumors. Here we report that the overabundance of potassium in the tumor microenvironment (TME) can explain both phenomena.

ORGANISM(S): Mus musculus

PROVIDER: GSE122156 | GEO | 2019/04/03

REPOSITORIES: GEO