Foxo signaling declines with age

ABSTRACT: We performed RNA-seq for WT and foxo mutant flies, by combining with Dr. Baihua's foxo chip-seq data, we found 101 foxo-repressed and 300 foxo-activated genes. By analyzing expression change of these genes during age, we found foxo-repressed genes became activated, while foxo-activated genes became repressed, suggesting foxo signaling declines with age.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE122470 | GEO | 2018/11/14

REPOSITORIES: GEO