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Transcriptomic analysis to functionally map the intrinsically disordered domain of EWS/FLI [Experiment 2]

ABSTRACT: The purpose of this study was to define unique classes of EWS/FLI target genes and the distinct set of structural features present in the EWS domain required for target gene regulation at different EWS/FLI response elements. This study reports the first genome-wide transcriptomic description of a partially-functional EWS/FLI mutant . We report new structure-function dependencies across different classes of response element and tie these dependencies to the ability of EWS/FLI to transform cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE122536 | GEO | 2019/02/21

REPOSITORIES: GEO

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Transcriptomic analysis to functionally map the intrinsically disordered domain of EWS/FLI [Experiment 1]

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