Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data of mesenchymal stromal cells derived from human bone marrow (BM-MSC) or autologous adipose tissues (ASC)

ABSTRACT: GEP on Affymetrix HuGene-1.0-ST arrays was performed on 14 BM-MSCs and 14 autologus paired ASCs in order to explore the biological significance of tissue source (bone marrow vs adipose tissue) in MSC production.

ORGANISM(S): Homo sapiens

PROVIDER: GSE122778 | GEO | 2019/08/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

MicroRNA expression profiling of extracellular vesicles derived from human BM-MSC

Project description:Human MSC are tissue stem cells that show multiple biological effects. At the present, how BM-MSC exert their effects are not fully understood. In this study, a novel cell-cell communication mediator, extraxellular vesicles (EV), were examined in the involvement of BM-MSC-mediated biological effects.

2018-05-21 | GSE99082 | GEO

BM-eGFP+ MSC expression arrays

Project description:original population (oMSC) and highly migrative subpopulation (sMSC) of murine eGFP+ bone marrow MSC

| EGAD00010001265 | EGA

Expression data from Bone-Marrow Mesenchymal Stromal Cells (BM-MSC) from Follicular Lymphoma patient (FL) or Healthy Donor (HD).

Project description:Human bone marrow mesenchymal stromal cells (BM-MSC) could be committed toward a functional lymphoid-like stroma by a combination of TNFalpha (TNF) and Lymphotoxin alpha1/beta2 (LT) (Amé-Thomas et al Blood 2007). Bone marrow and lymph node stromal cells support FL malignant cell recruitment and growth in particular after comittment to a lymphoid-like differentiation in vitro. In addition, more than 70% of FL patients exhibit a bone marrow involvment at diagnosis. We delineate using Affymetrix U133+2.0 microarrays the gene expression profile of BM-MSC obtained from FL patients (FL-MSC) and age-matched healthy donors (HD-MSC) in order to identify a specific FL-MSC signature. In addition, we used Affymetrix microarrays to define the gene expression signature of lymphoid-like stromal cells obtained from HD-MSC by treatment with TNF/LT in vitro. This TNF/LT signature was then used to interpret the gene expression profile of FL-MSC. GEP was performed on 10 BM-MSC from FL patients and 6 from healthy donors, treated or not with TNF(10 ng/mL)/LT(100ng/mL)

2012-01-26 | E-GEOD-35331 | biostudies-arrayexpress

Gene epression profile in human BM-MSC

Project description:Gene expression profiles of human BM-MSC isolated form normal donor to elucidate potential molecular network for clinical application

2010-10-02 | GSE19471 | GEO

Gene epression profile in human BM-MSC

Project description:Gene expression profiles of human BM-MSC isolated form normal donor to elucidate potential molecular network for clinical application Fresh isolated BM-MSC cells were cultured on defined condition. Functional assay was performed prior to gene expression analysis

2010-10-02 | E-GEOD-19471 | biostudies-arrayexpress

Expression data from five independent murine BM MSC

Project description:Data collected in our laboratory show that independent murine MSC cultures react in a heterogeneous manner to Toll-like receptors (TLRs) activation. This array aims to investigate the molecular basis for the heterogeneity in the response of MSCs to TLR activation and its origin.

2016-01-01 | GSE50560 | GEO

Gene Expression profile of brain in SCI rat by MSC intravenous transplantation.

Project description:We had analysed gene expression profile of brain in SCI rat by MSC. Compared with MSC intravenous and vehicle injection at SCI day3. We used Clariom D / Gene Chip® Rat Transcriptome Array (RTA 1.0., Affymetrix, Santa Clara, CA, USA).

2018-09-01 | GSE108168 | GEO

Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry

Project description:Mesenchymal stromal cells (MSC) are ideal candidates for cell therapies, due to their immune-regulatory and regenerative properties. We have previously reported that lung-derived MSC are tissue-resident cells with lung-specific properties compared to bone marrow-derived MSC. Assessing relevant molecular differences between lung-MSC and bone marrow-MSC is important, given that such differences may impact their behavior and potential therapeutic use. Here, we present an in-depth mass spectrometry (MS) based strategy to investigate the proteomes of lung-MSC and bone marrow-MSC. The MS-strategy relies on label free quantitative data-independent acquisition (DIA) analysis and targeted data analysis using a MSC specific spectral library. We identified several significantly differentially expressed proteins between lung-MSC and bone marrow-MSC within the cell layer (352 proteins) and in the conditioned medium (49 proteins). Bioinformatics analysis revealed differences in regulation of cell proliferation, which was functionally confirmed by decreasing proliferation rate through Cytochrome P450 stimulation. Our study reveals important tissue-specific differences within proteome and matrisome profiles between lung- and bone marrow-derived MSC that may influence their behavior and affect the clinical outcome when used for cell-therapy.

2018-10-18 | PXD006419 | Pride

Expression data of mesenchymal stromal cells derived from human bone marrow (BM-MSC) or autologous adipose tissues (ASC)

Project description:Expression data of mesenchymal stromal cells derived from human bone marrow (BM-MSC) or autologous adipose tissues (ASC)

| PRJNA506267 | ENA

Expression data from five independent murine BM MSC

2016-07-03 | E-GEOD-50560 | biostudies-arrayexpress