RNA sequencing of mutant AKT tumors

ABSTRACT: Goal: Comparison of mRNA expression profiles in primary tumors based on activation of different AKT paralogs Methods: RNA sequencing performed at the High-Throughput Genomics and Bioinformatics Analysis Core at the University of Utah. Detailed procedures available in methods and DNA processing pipline sections. Results: Focus of study compared mRNA expression profiles of BRAFV600E;Cdkn2a-/-;Pten-/- and BRAFV600E;Cdkn2a-/-;Pten-/-;AKT1E17K cohorts. PCA and unsupervised heirarchical clustering revealed samples clustered together appropriately. Seventeen of eighteen FA factor genes analyzed were upregulated in the AKT1E17K cohort. Conclusion: AKT1E17K has a critical role in upregulating a large group of FA factors

ORGANISM(S): Mus musculus

PROVIDER: GSE122781 | GEO | 2018/11/21

REPOSITORIES: GEO