Analysis of metastasis related gene in melanoma cells

ABSTRACT: We show that highly metastatic mouse melanoma B16/BL6 cells express less Gal-3 than B16 cells with a lower metastatic potential. We found that overexpression of Gal-3 in melanoma cells in fact suppresses metastasis. In contrast, knocking out Gal-3 expression in cancer cells promoted cell aggregation mediated through interactions with platelets and fibrinogen in vitro, and increased the number of metastatic foci in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE122789 | GEO | 2018/12/17

REPOSITORIES: GEO